BIOL - Biology Molecular Cell and Developmental

BIOL 15 Undergraduate Research Reports

Undergraduate students who work in faculty research laboratories present the results of their projects. Organized by the Minority Undergraduate Research Program and the Minority Access to Research Careers Program. Designed for students with membership in the above-mentioned programs. Prerequisite(s): qualifications as determined by instructor at first class meeting.

Credits

1

Instructor

Alan Zahler, Melissa Jurica

Repeatable for credit

Yes

Quarter offered

Fall, Spring

BIOL 20A Cell and Molecular Biology

Introduction to biochemistry, cell biology, molecular biology, and genetics.

Credits

5

Instructor

John Tamkun, Michael Rexach

Requirements

Prerequisite(s): CHEM 1A; students with a chemistry AP score of 4 or higher who wish to start their biology coursework prior to completing the CHEM 1A, may enroll by permission of the instructor.

Quarter offered

Fall, Winter, Spring, Summer

BIOL 20L Experimental Biology Laboratory

Provides biology majors with the theory and practice of experimental biology. A wide range of concepts and techniques used in the modern laboratory are included in the exercises. Designed to satisfy the introductory biology lab requirement of many medical and professional schools. Students are billed a materials fee.

Credits

2

Requirements

Prerequisite(s): BIOL 20A and previous or concurrent enrollment in BIOE 20B.

Quarter offered

Fall, Winter, Spring, Summer

BIOL 80A Female Physiology and Gynecology

Biochemical, medical, social, and clinical aspects of the female body. Emphasis will be on biological-chemical interactions in the female organs. Topics include female anatomy, cell physiology, endocrine functions, sexuality and intimacy, sexually transmitted diseases, puberty, pregnancy, menopause, birth control, abortion, immunity, cancer.

Credits

5

General Education Code

SI

Quarter offered

Spring

BIOL 80E Evolution

Introduction to Darwinian evolution including how the theory was devised and a discussion of other theories proposed at the time. Explores the facts and evidence of evolutionary processes and the insights they provide in biological diversity, consequences of extinction, and emergence of new diseases. Includes a discussion of evolution and spirituality.

Credits

5

General Education Code

SI

BIOL 80J Biology of Emerging and Pandemic Diseases

Designed to introduce non-biology majors to the biology of viruses, the human immune system, HIV/AIDS, and emerging viral pandemics. Also explores vaccine technology and viral mediated therapies. Social, political, and economic influences of HIV and other viral pandemics discussed.

Credits

5

General Education Code

PE-T

Quarter offered

Winter

BIOL 86 Research Deconstruction: MCD Biology

Explores scientific principles and logic through research seminars in molecular, cellular, and developmental biology. Additional topics may include diseases, stem cell biology, and other medically relevant areas in biomedical research. Prerequisite(s): Mathematics 3 or equivalent (i.e., mathematics placement examination score), and satisfaction of the Entry Level Writing and Composition requirements. Enrollment is restricted to first-year, sophomore, and junior students. Enrollment is by permission of the instructor.

Credits

3

Instructor

Grant Hartzog

Quarter offered

Spring

BIOL 88 Studies in Medicine: Its Art, History, Science, and Philosophy

An interdisciplinary, multicultural, and historical perspective of medicine focused primarily upon therapy and practice to achieve better understanding of the scope, practice, and limits or medicine.

Credits

5

Instructor

Grant Hartzog

Requirements

Prerequisite(s): satisfaction of the Entry Level Writing and Composition requirements.

General Education Code

SI

Quarter offered

Spring

BIOL 100 Biochemistry

An introduction to biochemistry including biochemical molecules, protein structure and function, membranes, bioenergetics, and regulation of biosynthesis. Provides students with basic essentials of modern biochemistry and the background needed for upper-division biology courses. Students who plan to do advanced work in biochemistry and molecular biology should take the Biochemistry and Molecular Biology 100 series directly. Students cannot receive credit for this course after they have completed any two courses from the BIOC 100A, BIOC 100B, and BIOC 100C sequence.

Credits

5

Instructor

Douglas Kellogg, Jeremy Sanford

Requirements

Prerequisite(s): BIOL 20A and BIOE 20B; and CHEM 8A or CHEM 112A.

Quarter offered

Fall, Winter, Spring

BIOL 100L Biochemistry Laboratory

Basic techniques and principles of laboratory biochemistry including isolation and characterization of a natural product, manipulation of proteins and nucleic acids to demonstrate basic physical and chemical properties; and characterization of enzyme substrate interactions. Students are billed a materials fee.

Credits

5

Requirements

Prerequisite(s): BIOL 100 or BIOC 100A; BIOL 101L or BIOL 102L; and satisfaction of the Entry Level Writing and Composition requirements. Enrollment is restricted to biological sciences and affiliated majors and biology minors. Non-majors may enroll by permission of the instructor.

BIOL 101 Molecular Biology

Covers the basic molecular mechanism of DNA replication and transcription, protein synthesis, and gene regulation in bacterial and eukaryotic organisms. The experimental techniques used to determine these mechanisms are emphasized. Unless students have already passed BIOL 20L, they are strongly encouraged to enroll in BIOL 101L.

Credits

5

Instructor

Melissa Jurica, Christopher Vollmers

Requirements

Prerequisite(s): BIOL 100 or BIOC 100A.

Quarter offered

Winter, Spring

BIOL 101L Molecular Biology Laboratory

Laboratory course providing hands-on experience with, and covering conceptual background in, fundamental techniques in molecular biology and biochemistry, including DNA cloning, PCR, restriction digest, gel electrophoresis, protein isolation, protein quantification, protein immunoblot (Western) analysis, and use of online bioinformatics tools. Students are billed a materials fee.

Credits

2

Requirements

Prerequisite(s): Previous or concurrent enrollment in BIOL 20L or BIOL 102J, and BIOL 101 or BIOC 100A is required. Students cannot receive credit for this course and BIOL 102L. Enrollment is restricted to biochemistry and molecular biology, biology B.S., molecular, cell, and developmental biology, and neuroscience majors.

Quarter offered

Winter, Spring, Summer

BIOL 102J Toxic RNA Lab I

Introduction to hypothesis-driven laboratory research. Students will create models of a unique uncharacterized disease causing mutation using site directed mutagenesis. An understanding of introductory molecular biology and genetics required. Students are billed a materials fee. Prerequisite(s): BIOL 20A. Enrollment restricted to biological sciences and affiliated majors with sophomore standing or higher. Enrollment by application and permission of instructor.

Credits

5

Quarter offered

Fall

BIOL 102L Toxic RNA Lab II

Introduces hypothesis-driven laboratory research. Students create models of a unique uncharacterized disease causing mutation and determine how it impacts the process of pre-mRNA splicing. An understanding of introductory molecular biology and genetics is required. Students are billed a materials fee. Prerequisite(s): BIOL 20A; and BIOL 20L or BIOL 102J. Enrollment is restricted to sophomore, junior, and senior biological sciences and affiliated majors. Enrollment is by application and permission of the instructor.

Credits

5

General Education Code

PR-E

Quarter offered

Winter

BIOL 103L Toxic RNA Lab III

Introduces hypothesis-driven laboratory research. Students create models of a unique, uncharacterized, disease-causing mutation and determine how it impacts the process of pre-mRNA splicing. An understanding of introductory molecular biology and genetics is required. Prerequisite(s): BIOL 102J and BIOL 102L and satisfaction of the Entry Level Writing and Composition is requirements. Enrollment is restricted to sophomores, juniors, and seniors majoring in biology, molecular, cell, and developmental biology, neuroscience, human biology, and biochemistry and molecular biology. Enrollment is by application and permission of the instructor.

Credits

5

Quarter offered

Spring

BIOL 105 Genetics

Mendelian and molecular genetics; mechanisms of heredity, mutation, recombination, and gene action.

Credits

5

Instructor

Susan Strome, Jeremy Lee, Needhi Bhalla

Requirements

Prerequisite(s): BIOL 20A and BIOE 20B.

Quarter offered

Fall, Winter, Spring, Summer

BIOL 105L Eukaryotic Genetics Laboratory

Classical and newly developed molecular-genetic techniques used to explore genetic variation in wild populations of the fruit fly Drosophila melanogaster. Topics include Mendelian fundamentals, mapping, design of genetic screens, bio-informatic and database analysis, genetic enhancers, and population genetics. Students are billed a materials fee. Enrollment is restricted to biological sciences and affiliated majors; biology minors; non-majors by instructor permission.

Credits

5

Instructor

The Staff

Requirements

Prerequisite(s): BIOL 100 or BIOC 100A; BIOL 101L or BIOL 102L; BIOL 105; and satisfaction of the Entry Level Writing and Composition Requirements.

Quarter offered

Fall, Winter, Spring

BIOL 109L Yeast Molecular Genetics Laboratory

Using budding yeast as an experimental organism, this laboratory provides practical experience in classic and modern molecular biology and in genetic and epigenetic methods, and develops strong scientific communication skills. Topics include mendelian genetics, linkage, gene replacement, chromatin immunoprecipitation and epigenetics. Students are billed a materials fee.

Credits

5

Requirements

Prerequisite(s): BIOL 101 or BIOC 100A; and BIOL 101L or BIOL 102L, and BIOL 105. BIOL 115 strongly recommended. Satisfaction of the Entry Level Writing and Composition requirements. Enrollment is restricted to biological sciences and affiliated majors; biology minors. Non-majors enroll by instructor permission.

Quarter offered

Fall, Winter, Spring

BIOL 110 Cell Biology

Covers the structure, organization, and function of eukaryotic cells. Topics include biological membranes, organelles, protein and vesicular trafficking, cellular interactions, the cytoskeleton, and signal transduction. Requires a good understanding of basic biochemistry and molecular biology.

Credits

5

Instructor

Lindsay Hinck, Michael Rexach

Requirements

Prerequisite(s): BIOL 101 or BIOC 100A; and BIOL 105; and BIOL 101L or BIOL 102L or BIOL 20L.

Quarter offered

Fall, Winter, Spring

BIOL 111 Immunology

Immune systems--their manifestations and mechanisms of action.

Credits

5

Requirements

Prerequisite(s): BIOL 20A, BIOE 20B, BIOL 105, and BIOL 110.

BIOL 111A Immunology I

Principles and concepts of the innate and adaptive immune systems, with emphasis on mechanisms of action and molecular and cellular networks. The development, differentiation, and maturation of cells of the immune system are also discussed.

Credits

5

Instructor

Susan Carpenter

Requirements

Prerequisite(s): courses BIOE 20B, BIOL 20A, BIOL 105, and BIOL 110.

Quarter offered

Winter

BIOL 111B Immunology II

The immune system in health and disease, including failures of host immune-defense mechanisms, allergy and hypersensitivity, autoimmunity, transplantation biology, the immune response to tumors, immune-system interactions with pathogens, and manipulation of the immune response.

Credits

5

Instructor

Martha Zuniga

Requirements

Prerequisite(s): BIOL 111A.

Quarter offered

Spring

BIOL 112 Virology

Principles of virology illustrated through study of specific examples. Topics include: viral genome organization, viral assembly, virus-host interactions, genetic diversity of viruses, viral ecology, and the epidemiology of viral diseases. Prerequisite(s): BIOL 101 and 110 and consent of instructor.

Credits

3

Instructor

Martha Zuniga

Quarter offered

Winter

BIOL 114 Cancer Cell Biology

Focuses on the molecular and cellular mechanisms behind cancer. Topics covered include oncogenes, tumor suppressor genes, cell growth genes, checkpoint genes, telomeres, and apoptosis. Students will gain experience in reading the primary scientific literature.

Credits

5

Instructor

Alan Zahler

Requirements

Prerequisite(s): BIOL 110 or BIOL 115.

General Education Code

TA

Quarter offered

Spring

BIOL 115 Eukaryotic Molecular Biology

Covers eukaryotic gene and genome organization; DNA, RNA, and protein synthesis; regulation of gene expression; chromosome structure and organization; and the application of recombinant DNA technology to the study of these topics.

Credits

5

Instructor

Hanns Boeger

Requirements

Prerequisite(s): BIOL 101 or BIOC 100A; and BIOL 105; and BIOL 101L or BIOL 102L. Enrollment restricted to biological sciences and affiliated majors, non-majors by permission of instructor.

Quarter offered

Winter

BIOL 115L Eukaryotic Molecular Biology Laboratory

A laboratory designed to provide students with direct training in basic molecular techniques. Each laboratory is a separate module which together builds to allow cloning, isolation, and identification of a nucleic acid sequence from scratch. Students cannot receive credit for this course and BIOL 187L or BIOL 287L. Students are billed a materials fee.

Credits

5

Requirements

Prerequisite(s): BIOL 100 or BIOC 100A; BIOL 101L or BIOL 102L; and satisfaction of the Entry Level Writing and Composition Requirements; and previous or concurrent enrollment in BIOL 101 or BIOL 115. Restricted to molecular, cell and developmental biology majors and affiliated majors; biology minors; other majors by permission.

Quarter offered

Fall, Winter, Spring

BIOL 116 Advanced Topics in Cell Biology

Advanced course in cell biology featuring small-classroom discussion of topics related to the structure and function of cells and their organelles. Emphasis is given to experimental strategies used in cell biology research. Requires discussion of scientific literature and student-led presentations.

Credits

3

Instructor

Michael Rexach

Requirements

Prerequisite(s): BIOL 110. Enrollment is restricted to senior human biology, molecular, cell, and developmental biology, and neuroscience majors. Other majors by permission of instructor.

Quarter offered

Spring

BIOL 117 Global Health and Neglected Diseases

Neglected tropical diseases afflict more than 1 billion of the poorest individuals on the planet. This course covers the molecular basis and pathology of the most prevalent neglected diseases and emerging strategies to combat these diseases. (Formerly Neglected Tropical Diseases.)

Credits

3

Instructor

William Sullivan

Requirements

Prerequisite(s): BIOL 110. Enrollment is restricted to senior human biology, molecular, cell, and developmental biology, and neuroscience majors. Other majors by permission of instructor.

Quarter offered

Fall

BIOL 120 Developmental Biology

A description and analysis of selected developmental events in the life cycle of animals. Experimental approaches to understanding mechanisms are emphasized. (Formerly Development.)

Credits

5

Instructor

Zhu Wang

Requirements

Prerequisite(s): BIOL 110.

Quarter offered

Winter

BIOL 120L Development Laboratory

Experimental studies of animal development using a variety of locally obtainable organisms. Approximately eight hours weekly, but it will often be necessary to monitor continuing experiments throughout the week. Students are billed a materials fee.

Credits

5

Requirements

Prerequisite(s): BIOL 100 or BIOC 100A; and BIOL 101L or BIOL 102L; satisfaction of the Entry Level Writing and Composition requirements. Previous or concurrent enrollment in BIOL 120 is required. Enrollment is restricted to biological sciences and affiliated majors; biology minors; other majors by permission.

Quarter offered

Winter

BIOL 121L Environmental Phage Biology Laboratory

Introduction to hypothesis-driven laboratory research. Students isolate a unique bacteriophage and characterize its structure and genome. An understanding of molecular biology and basic genetics is required. Students are billed a materials fee. Prerequisite(s): BIOL 100 or BIOC 100A; and BIOL 101L or 102L; satisfaction of the Entry Level Writing and Composition requirements. Enrollment is restricted to biological sciences and affiliated majors with sophomore standing or higher. Enrollment is by application and permission of instructor.

Credits

5

BIOL 125 Introduction to Neuroscience

The structure and function of the nervous system. Topics include elementary electrical principles, biophysics and physiology of single nerve and muscle cells, signal transduction at synapses, development of the nervous system, and neural basis of behavior. Requires a good understanding of basic biochemistry, cell biology, and molecular biology.

Credits

5

Instructor

James Ackman

Requirements

Prerequisite(s): BIOL 20A, BIOE 20B; and BIOL 101 or BIOC 100A; previous or concurrent enrollment in BIOL 110 is required.

Quarter offered

Fall, Winter

BIOL 126 Advanced Molecular Neuroscience

Explores in detail cellular and molecular events that underlay the function of the nervous system. Topics include neural development, axon guidance and regeneration, advanced electrical principles (synaptic transmission through a variety of receptors), synaptic plasticity, learning and memory, as well as several neural disorders. Students cannot receive credit for this course and course 226.

Credits

5

Instructor

David Feldheim, Yi Zuo

Requirements

Prerequisite(s): BIOL 125. Enrollment is restricted to neuroscience majors and proposed majors.

General Education Code

TA

Quarter offered

Spring

BIOL 127 Mechanisms of Neurodegenerative Disease

Focuses on cellular and molecular processes that underlie neurodegenerative diseases. Includes lectures, student oral presentations, discussions, a term paper, and exams.

Credits

5

Instructor

William Saxton

Requirements

Prerequisite(s): BIOL 110.

BIOL 128 Developmental Neurobiology

Covers the principles of nervous-system development from the molecular control of development, cell-cell interactions, to the role of experience in influencing brain structure and function. Students cannot receive credit for this course and course 228.

Credits

5

Instructor

Bin Chen

Requirements

Prerequisite(s): BIOL 110 and BIOL 125. Enrollment is restricted to juniors and seniors.

Quarter offered

Winter

BIOL 130 Human Physiology

Function, organization, and regulation of the major organ systems of humans, with emphasis on integration among systems. Students cannot receive credit for this course and course 131.

Credits

5

Requirements

Prerequisite(s): BIOL 110.

Quarter offered

Fall, Winter, Summer

BIOL 130L Human Physiology Laboratory

Examines fundamental principles of systemic physiology focusing on the human. Students cannot receive credit for this course and BIOE 131L. Students are billed a materials fee.

Credits

2

Requirements

Prerequisite(s): BIOL 110; BIOL 20L or 102J; and previous or concurrent enrollment in BIOL130 is required.Satisfaction of Entry Level Writing and Composition requirements. Enrollment is restricted to biological sciences and affiliated majors; biology minors; other majors by permission.

Quarter offered

Fall, Winter, Summer

BIOL 140 The RNA World

This active-learning course explores the origins, evolution, and functions of ribonucleic acid (RNA), including ribozymes, ribosomes, IRNAs, spliceosomes, riboswitches, messenger RNA, microRNAs, snRNAs, snoRNAs, and other guide RNAs, CRISPR, long noncoding RNAs, retrotransposons, and RNA viruses.

Credits

5

Requirements

Prerequisite(s): BIOL 105 or BME 105, and BIOL 101.

Quarter offered

Spring

BIOL 186F Undergraduate Research in MCD Biology

Supervised undergraduate research in laboratory of an MCD biology faculty member accompanied by weekly lectures on ethical and practical scientific issues. Topics include: laboratory safety; the scientific method; the collection, treatment, and presentation of data; critical evaluation of scientific literature; scientific misconduct; and peer review. Career issues, including how to apply for admission to graduate and professional schools, are also discussed. Prerequisite(s): BIOL 100 or BIOC 100A; and BIOL 20L or BIOL 102J; and previous completion of the Disciplinary Communication requirement. Each enrolled student must have a committed MCD faculty sponsor by the first class meeting. Enrollment is restricted to biology and affiliated majors.

Credits

2

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 186L Undergraduate Research in MCD Biology

Supervised undergraduate research in laboratory of an MCD biology faculty member accompanied by weekly lectures on ethical and practical scientific issues. Topics include: laboratory safety; the scientific method; the collection, treatment, and presentation of data; critical evaluation of scientific literature; scientific misconduct; and peer review. Career issues, including how to apply for admission to graduate and professional schools, are also discussed. Prerequisite(s): Entry Level Writing and Composition requirements; BIOL 100 or BIOC 100A; and BIOL 20L or BIOL 102J. Each enrolled student must have a committed MCD faculty sponsor by the first class meeting. Enrollment is restricted to biology and affiliated majors.

Credits

5

Quarter offered

Fall, Winter, Spring

BIOL 186R Undergraduate Research in MCD Biology

Supervised undergraduate research in the laboratory of an MCD biology faculty member accompanied by weekly lectures on practical scientific issues. Topics include: laboratory safety; the scientific method; the collection, treatment, and presentation of data; critical evaluation of scientific literature; ethics and scientific misconduct; and peer review. Career issues, including how to apply for admission to graduate and professional schools, are discussed. Students cannot receive credit for this course and course 186L. Prerequisite(s): BIOL 100 or BIOC 100A; and BIOL 20L or BIOL 102J; and previous completion of the Disciplinary Communication requirement. Each enrolled student must have a committed MCD faculty sponsor by the first class. Enrollment is restricted to MCD Biology-affiliated majors.

Credits

5

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 188 A Life in Medicine

Students explore healthcare from the perspectives of both clinicians and patients. The class focuses on medicine's cognitive, emotional, and spiritual elements, with the goal of understanding the rewards and costs of healthcare practice. (Formerly Life in Healthcare.)

Credits

3

Requirements

Enrollment is restricted to junior and senior human biology majors, and others by permission of instructor.

General Education Code

PR-E

Quarter offered

Fall, Spring

BIOL 189 Health Sciences Internship

Structured off-campus learning experience providing experience and pre-professional mentoring in a variety of health-related settings. Interns are trained and supervised by a professional at their placement and receive academic guidance from their faculty sponsor. Students spend 8 hours per week at their placement, participate in required class meetings on campus, and keep a reflective journal. Enrollment is by application. Students interview with health sciences internship coordinator; applications are due one quarter in advance to the Health Sciences Internship Office. Prerequisite(s): satisfaction of the Entry Level Writing and Composition requirements; previous or concurrent enrollment in course 189W is required. Enrollment is restricted to human biology majors.

Credits

3

Instructor

Lindsay Hinck, Martha Zuniga, Michael Rexach

Quarter offered

Fall, Winter, Spring, Summer

BIOL 189W Disciplinary Communication: Human Biology

Writing-intensive course offered in conjunction with the health sciences internship. Weekly class meetings include academic guidance and mentoring as well as discussion of the mechanisms and conventions of academic writing about heath and health care. Students complete multiple writing assignments, culminating in a term paper in the format of a scholarly article. Enrollment is by application. Students interview with the health-sciences internship coordinator; applications are due one quarter in advance to the Health Care Sciences Internship Office. Prerequisite(s): satisfaction of the Entry Level Writing and Composition requirements. Previous or concurrent enrollment in course 189 is required. Enrollment is restricted to human biology majors.

Credits

2

Instructor

Lindsay Hinck, Martha Zuniga, Michael Rexach

Quarter offered

Fall, Winter, Spring, Summer

BIOL 195 Senior Thesis Research

An individually supervised course, with emphasis on independent research, to culminate in a senior thesis. Students submit petition to sponsoring agency.

Credits

5

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 198 Independent Field Study

Provides for individual programs of study (a) by means other than the usual supervision in person, or (b) when the student is doing all or most of the coursework off campus. With permission of the department, may be repeated for credit, or two or three courses taken concurrently. Students submit petition to sponsoring agency.

Credits

5

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 198F Independent Field Study

Provides for two credits of independent field study (a) by means other than the usual supervision in person, or (b) when the student is doing all or most of the coursework off campus. Students submit petition to sponsoring agency.

Credits

2

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 199 Tutorial

Reading, discussion, written reports, and laboratory research on selected biological topics, using facilities normally available on campus. Students submit petition to sponsoring agency.

Credits

5

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 199F Tutorial

Two-credit Tutorial. Reading, discussion, written reports, and laboratory research on selected biological topics, using facilities normally available on campus. Students submit petition to sponsoring agency.

Credits

2

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 200A Critical Analysis of Scientific Literature

Development of critical thinking skills via discussion of research articles on a broad range of topics. Prepares students to critically evaluate research publications, and improves their ability to organize effective oral presentations and to evaluate the oral presentations of other scientists.

Credits

5

Instructor

John Tamkun, Jeremy Sanford

Requirements

Enrollment is restricted to graduate students in MCD biology, or by permission of instructor.

Quarter offered

Fall

BIOL 200B Advanced Molecular Biology

An in-depth coverage of the structure, function, and synthesis of DNA, RNA, and proteins. Discussion of the roles of macromolecules in the regulation of information in the cell.

Credits

5

Instructor

Alan Zahler, Melissa Jurica, Hanns Boeger

Requirements

Prerequisite(s): Enrollment is restricted to graduate students.

Quarter offered

Winter

BIOL 200C Advanced Cell Biology

An in-depth coverage of topics in cellular and subcellular organization, structure, and function in plants and animals. Emphasis on current research problems.

Credits

5

Instructor

Douglas Kellogg, William Saxton, Needhi Bhalla

Requirements

Prerequisite(s): BIOL 200B. Enrollment is restricted to graduate students.

Quarter offered

Spring

BIOL 200D Developmental Biology

Key topics in developmental biology, including developmental genetics, epigenetics, stem cell biology, and developmental neurobiology. Lectures are accompanied by critical analysis and discussion of recent publications.

Credits

5

Instructor

Susan Strome, Bin Chen, Zhu Wang

Requirements

Enrollment is restricted to graduate students in MCD biology, or by permission of instructor.

Quarter offered

Spring

BIOL 200E Experimental Design

A multidisciplinary course that focuses on topics to consider when tackling biomedical research questions experimentally. Lectures highlight important issues to take into account, are coupled with group discussions and intensive analysis of primary literature, and involve case studies to practically demonstrate how how these considerations might be implemented.

Credits

3

Requirements

Concurrent enrollment in BIOL 200A is required.

BIOL 200F Logic and Approaches to Scientific Discovery

Multidisciplinary course with an emphasis on discussion of approaches and methods involved in the study of biological questions. Lectures focus on current gaps in our knowledge of topics and approaches to test models and hypotheses. Course focuses on current topics in RNA and DNA molecular biology, cell biology, developmental biology, stem cells, neurobiology, and genomics. Lectures coupled with small group discussions and written assignments.

Credits

5

Requirements

Prerequisite(s): BIOL 200A. Enrollment is restricted to graduate students.

BIOL 201 RNA Processing

An advanced graduate-level course on biological aspects of RNA function and processing in eukaryotes. Lectures and discussions will be developed using the current literature.

Credits

5

Instructor

Manuel Ares, Melissa Jurica

Requirements

Prerequisite(s): BIOL 200B or permission of instructor. Enrollment is restricted to graduate students.

BIOL 203 Ribosomes and Translation

Covers the field of ribosome research in depth, including the structure and function of ribosomes and the molecular mechanisms of protein synthesis. Begins with historical review of the ribosome field and proceeds to the most recent findings. Focus is on central questions: (1) How is the accuracy of the aminoacyl-tRNA selection determined? (2) What is accommodation? (3) What is the mechanism of peptide bond formation (peptidyl transferase)? (4) What is the mechanism of translocation? (5) What are the mechanistic roles of the ribosome and translation factor EF-G in translocation? (6) To what extent is the mechanism of translation determined by RNA? (7) Why is RNA so well suited for the ribosome? (8) How did translation evolve from an RNA world?

Credits

5

Requirements

Prerequisite(s): BIOC 100A, BIOL 200B or permission of instructor. Enrollment is restricted to graduate students.

BIOL 204 Chromatin

Eukaryotic DNA is complexed with histones to form chromatin. This course focuses on the ways in which chromatin influences and is manipulated to regulate gene expression

Credits

5

Instructor

Grant Hartzog, John Tamkun

Requirements

Prerequisite(s): BIOL 105 and BIOL 115; undergrads by permission of instructor. Enrollment is restricted to graduate students.

BIOL 205 Epigenetics

In-depth coverage of epigenetics focusing on how alterations in chromatin structure and DNA methylation establish and maintain heritable states of gene expression. Lectures are supplemented with critical discussion of recent publications.

Credits

5

Instructor

John Tamkun, Susan Strome

Requirements

Prerequisite(s): BIOL 105 and BIOL 115, or permission of instructor. Enrollment is restricted to graduate students.

BIOL 206 Introduction to Stem Cell Biology

Fundamental concepts, experimental approaches, and current advances in stem cell biology, with consideration of key ethical issues. Topics include: self-renewal and differentiation; the microenvironment; epigenetics; cell-cycle regulation; and how basic research translates to medical therapeutics. Ethical, moral, and political issues surrounding stem cell research are discussed with lectures from philosophy and other relevant disciplines.

Credits

5

Instructor

William Sullivan

Requirements

Enrollment is restricted to graduate students.

BIOL 206L Current Protocols in Stem Cell Biology

Provides students with hands-on experience in embryonic stem cell culture methods.

Credits

5

Instructor

David Feldheim, Yi Zuo

Requirements

Enrollment is restricted to graduate students; qualified undergraduates may enroll by permission of instructor.

BIOL 208 Cellular Signaling Mechanisms

All eukaryotic cells utilize intricate signaling pathways to control such diverse events as cell-cell communication, cell division, and changes in cell morphology. This course covers the molecular basis of these cellular signaling pathways, focusing on the most current research.

Credits

5

Instructor

Douglas Kellogg

Requirements

Prerequisite(s): BIOL 105, BIOL 110, and BIOL 115. Enrollment is restricted to seniors and graduate students.

BIOL 214 Advances in Cancer Biology

Provides students with knowledge of the latest concepts in cancer biology and cancer therapeutics, and a general appreciation of the rapid advances being made in this area of biomedicine.

Credits

5

Instructor

Lindsay Hinck

Requirements

Prerequisite(s): BIOL 200B or by permission of instructor. Enrollment is restricted to graduate students.

BIOL 215 Applied Statistics for Molecular, Cell, and Developmental Biology

For experimental biologists: focuses on resolving practical statistical issues typically encountered in molecular, cellular, and developmental biology lab research. No prior experience in statistics or programming is necessary.

Credits

5

Requirements

Enrollment is restricted to graduate students in molecular, cellular, and developmental biology.

BIOL 217 Influence of Environment and Experience on Brain Development

How environmental factors (animals' experiences, environmental toxins, etc.) affect the formation of neuronal circuits and brain function. Lectures and discussions use current literature.

Credits

5

Instructor

Donald Smith, Yi Zuo

Requirements

Prerequisite(s): BIOL 200A, BIOL 200B, BIOL 200C, and BIOL 200D, or by permission of the instructor. Enrollment is restricted to graduate students.

Quarter offered

Winter

BIOL 218 CRISPR/Cas Technologies

Provides an overview of the continually emerging roles for CRISPR in biomedical research. Topics will include an overview of the CRISPR genome defense systems in bacteria, the mechanisms of DNA cleavage and repair, the many uses of CRISPR as a genome editing tool in model organisms, and discussions on the ethical use of the technology in precision medicine.

Credits

5

Requirements

Prerequisite(s): BIOL 200A, BIOL 200B, and BIOL 200C. Enrollment restricted to graduate students.

Quarter offered

Fall

BIOL 226 Advanced Molecular Neuroscience

Basis of neural behavior at the cellular, molecular and system levels. First half of course focuses on cellular, molecular, and developmental aspects of the nervous system and covers two sensory systems: olfaction and auditory. Last half of course concerns higher-level functions of the nervous system, such as processing and integrating information. Discusses human diseases and disorders.

Credits

5

Instructor

Yi Zuo

Requirements

Enrollment is restricted to graduate students.

Quarter offered

Spring

BIOL 228 Developmental Neurobiology

Covers the principles of nervous-system development from the molecular control of development, and cell-cell interactions, to the role of experience in influencing brain structure and function. Students cannot receive credit for this course and course 128. Enrollment is restricted to graduate students and by permission of the instructor.

Credits

5

Instructor

Bin Chen

Quarter offered

Winter

BIOL 280A Topics in Research on Molecular Genetics of Yeast

Intensive research seminar on the structure and function of the gene expression machinery in the simple eukaryote Saccharomyces cervisiae and its relationship to the human gene expression machinery.

Credits

2

Instructor

Manuel Ares

Requirements

Enrollment is restricted to graduate students; qualified undergraduates may enroll with approval of instructor.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 280B Chromatin Structure and Transcriptional Regulation

Weekly seminar on structure and gene regulatory function of chromatin. Discusses research of participants and relevant scientific literature.

Credits

2

Instructor

Hanns Boeger

Requirements

Enrollment is restricted to graduate students; qualified undergraduates may enroll with permission of instructor.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 280C Mammalian Brain Development

Seminar covers research into the development of the mammalian brain.

Credits

2

Instructor

Bin Chen

Requirements

Enrollment is restricted to graduate students; undergraduates may enroll with permission of instructor.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 280D RNA Processing

A discussion of current research and literature concerning the regulation of precursor messenger RNA processing.

Credits

2

Instructor

Alan Zahler

Requirements

Enrollment is restricted to graduate students; qualified undergraduates may enroll with permission of instructor.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 280E Meiotic Chromosome Dynamics

Intensive course on the molecular mechanisms underlying homolog pairing, synapses, and recombination; and how they are regulated, coordinated, and monitored to ensure accurate meiotic chromosome segregation.

Credits

2

Instructor

Needhi Bhalla

Requirements

Enrollment is restricted to graduate students; undergraduates may enroll with permission of instructor.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 280F Development of Vertebrate Neural Connections

Intensive research seminar on molecular mechanisms by which neural connections are established during mouse development. Special focus on topographic maps and role of Eph receptors and ephrins in this process.

Credits

2

Instructor

David Feldheim

Requirements

Enrollment is restricted to graduate students; qualified undergraduates may enroll with permission of instructor.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 280G Physiology of the Developing Brain

Research seminar covering circuit structure and function in the developing brain.

Credits

2

Instructor

James Ackman

Requirements

Enrollment is restricted to graduate students; undergraduates may enroll by permission of the instructor.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 280H Topics on Research into Chromatin and Transcription

Seminar covering research into the effects of chromatin on transcription in yeast.

Credits

2

Instructor

Grant Hartzog

Requirements

Enrollment is restricted to graduate students; undergraduates may enroll with permission of instructor.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 280I Epigenetic Gene Silencing and Insulators

Intensive course on molecular mechanisms by which insulator elements regulate epigenetic gene silencing.

Credits

2

Instructor

Rohinton Kamakaka

Requirements

Enrollment is restricted to graduate students; qualified undergraduates may enroll with permission of instructor.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 280J Structures of Macromolecular Complexes

Focuses on structure and function of the spliceosome using electron microscopy and x-ray crystallography. Participants present results from their own research and relevant journal articles.

Credits

2

Instructor

Melissa Jurica

Requirements

Enrollment is restricted to graduate students; qualified undergraduates may enroll with permission of instructor.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 280K Topics in Cell Cycle Research

An intensive seminar focusing on current research on the molecular mechanisms that control cell division. Participants are required to present results of their own research or to review journal articles of interest.

Credits

2

Instructor

Douglas Kellogg

Requirements

Enrollment is restricted to graduate students; qualified undergraduates may enroll with permission of instructor.

Quarter offered

Fall, Winter, Spring

BIOL 280L Development

Seminar covering research into breast development and cancer. (Formerly Topics on Neural Development.)

Credits

2

Instructor

Lindsay Hinck

Requirements

Enrollment is restricted to graduate students.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 280M Post-Transcriptional Control of Mammalian Gene Expression

Intensive course on the molecular mechanisms by which RNA binding proteins regulate gene expression.

Credits

2

Instructor

Jeremy Sanford

Requirements

Enrollment is restricted to graduate students; qualified undergraduates may enroll with the permission of the instructor.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 280N Long Noncoding RNA and the Immune System

Weekly seminar discussion of the current research and literature concerning the functions for long noncoding RNA in gene regulation within inflammatory signaling pathways.

Credits

2

Instructor

Susan Carpenter

Requirements

Enrollment is restricted to graduate students; qualified undergraduates may enroll by permission of the instructor.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 280P Quality Control in Gene Expression

Intensive, discussion-based course concerning ongoing research in quality control and gene expression via analysis of published and unpublished observations and theories.

Credits

2

Instructor

Joshua Arribere

Requirements

Enrollment is restricted to graduate students.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 280Q Cell Biology of Oocytes, Embryos, and Neurons

Weekly seminar and round-table discussion about research problems and recent advances in molecular motor proteins, cytoskeletons, and the control of force-producing processes. Each participant reports recent advances in their field from current literature, their own primary research questions, current approaches to answering those questions, and their research progress.

Credits

2

Instructor

William Saxton

Requirements

Enrollment is restricted to graduate students; undergraduates may enroll with permission of instructor.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 280R Gene regulation in C. elegans and human parasitic namtodes

Intense weekly seminar on the mechanisms of gene regulation, focusing on C. elegans and human parasitic nematodes.

Credits

2

Instructor

Jordan Ward

Requirements

Enrollment is restricted to graduate students; qualified undergraduates may enroll with the permission of the instructor.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 280S Chromatin and RNA Regulation in <i>C. elegans</i>

Intensive research seminar about regulators of chromatin organization; the composition and function of germ granules; and the roles of both levels of regulation in germline development in C. elegans. Participants present their research results and report on related journal articles.

Credits

2

Instructor

Susan Strome

Requirements

Enrollment is restricted to graduate students; undergraduates may enroll with permission of instructor.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 280T Molecular Biology of <I>Drosophila</I> Development

An intensive seminar concerning the molecular genetics of Drosophila. Recent research is discussed weekly, with an emphasis on gene regulation and development. Students present their own research or critical reviews of recent articles at least once during the quarter.

Credits

2

Instructor

John Tamkun

Requirements

Enrollment is restricted to graduate students. Qualified undergraduates may enroll with permission of instructor.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 280U Discussions on the Development of the <I>Drosophila</I> Embryo

Involves a two-hour weekly meeting in which the students discuss topics concerning the cell cycle, early embryonic development, and the cytoskeleton. These discussions critically evaluate ongoing research in this area. Material is drawn from student research and recently published journal articles. Students are also expected to meet individually with the instructor two hours weekly. In addition to a three–five page research proposal, each student gives two one-hour oral presentations.

Credits

2

Instructor

William Sullivan

Requirements

Enrollment is restricted to graduate students; qualified undergraduates may enroll with permission of instructor.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 280V Translational pediatric genomics

Weekly discussion of the current research and literature on translational pediatric genomics. Specific patient cases may be discussed.

Credits

2

Requirements

Enrollment is restricted to graduate students; qualified undergraduates may enroll by permission of the instructor.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 280W Development, Connectivity, and Genetic Identity of Neural Circuits

This seminar course will cover the current topics and progress of neuroscience research on neural circuit development, connectivity, function and genetics. (Formerly Membrane Proteins.)

Credits

2

Requirements

Enrollment is restricted to graduate students; qualified undergraduates may enroll with permission of instructor.

Repeatable for credit

Yes

Quarter offered

Fall

BIOL 280X RNA-mediated epigenetic inheritance

Intensive research seminar about epigenetic inheritance and the role of small non-coding RNAs in the intergenerational inheritance of paternal environmental effects. Participants present their research results and report on related journal articles.

Credits

2

Requirements

Enrollment is restricted to graduate students; qualified undergraduates may enroll by permission of the instructor.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 280Y Activity-Dependent Synaptic Plasticity

Research seminar covering the regulation of synaptic plasticity in the mammalian nervous system, focusing on how the activity regulates the structural and functional dynamics of synapses.

Credits

2

Instructor

Yi Zuo

Requirements

Enrollment is restricted to graduate students; undergraduates may enroll with permission of instructor.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 280Z Prostate Development and Cancer Biology

Weekly research seminar covering gene regulation, cellular interactions, and stem cell behaviors in mammalian prostate development and prostate cancer progression.

Credits

2

Instructor

Zhu Wang

Requirements

Enrollment is restricted to graduate students; undergraduates may enroll by the permission of the instructor.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 288 Pedagogy in STEM

Prepares graduate students to help teach university science courses. Weekly class sessions include activities and interactive discussions of diverse modes of learning, diverse ways of teaching, peer instruction, assessment of learning, equity and inclusion, and professional ethics. Students also visit an active learning class and an active learning discussion section at UCSC, then write evaluations of the teaching strategies used in those classes. (Formerly Teaching Assistant Training.)

Credits

2

Instructor

Melissa Jurica, Susan Strome

Requirements

Enrollment is restricted to graduate students.

Quarter offered

Fall

BIOL 289 Practice of Science

Examination of ethical and practical scientific issues, including the collection and treatment of data, attribution of credit, plagiarism, fraud, and peer review. Career issues, including how to apply for grants and positions in industry or academia, will be discussed.

Credits

5

Instructor

William Saxton

Requirements

Prerequisite(s): BIOL 200A, BIOL 200B, and BIOL 200C or permission of instructor. Enrollment is restricted to graduate students; undergraduates may enroll with permission of the instructor.

Quarter offered

Spring

BIOL 290 Career Planning

An important goal of graduate programs is to train students for diverse careers. Exposes molecular cell and developmental biology graduate students to diverse career options and helps them develop individual development plans to target their graduate training to their selected career goals.

Credits

2

Instructor

Needhi Bhalla

Requirements

Enrollment is restricted to graduate students.

BIOL 291 Molecular, Cellular, and Developmental Biology Seminar

Topics of current interest in molecular, cellular, and developmental biology are presented weekly by graduate students, faculty, and guest speakers.

Credits

2

Instructor

David Feldheim

Requirements

Enrollment is restricted to graduate students.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 292 MCD Seminar

Various topics by weekly guest speakers.

Credits

0

Instructor

David Feldheim

Requirements

Enrollment is restricted to graduate students.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 296 Laboratory Research in Molecular, Cell, and Developmental Biology

Independent laboratory research in molecular, cellular, and developmental biology. Students submit petition to sponsoring agency.

Credits

5

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 297A Independent Study

Independent study for graduate students who have not yet settled on a research area for their thesis. Students submit petition to sponsoring agency.

Credits

5

Repeatable for credit

Yes

BIOL 297B Independent Study

Independent study for graduate students who have not yet settled on a research area for their thesis. Students submit petition to sponsoring agency.

Credits

10

Repeatable for credit

Yes

BIOL 297C Independent Study

Independent study for graduate students who have not yet settled on a research area for their thesis. Students submit petition to sponsoring agency.

Credits

15

Repeatable for credit

Yes

BIOL 297F Independent Study

Independent study for graduate students who have not yet settled on a research area for their thesis. Students submit petition to sponsoring agency.

Credits

2

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring, Summer

BIOL 299A Thesis Research

Students submit petition to sponsoring agency.

Credits

5

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 299B Thesis Research

Students submit petition to sponsoring agency.

Credits

10

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 299C Thesis Research

Students submit petition to sponsoring agency.

Credits

15

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 299F Thesis Research

Students submit petition to sponsoring agency.

Credits

2

Requirements

Enrollment is restricted to graduate students.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring, Summer