Upper-Division

BIOL 100 Biochemistry

An introduction to biochemistry including biochemical molecules, protein structure and function, membranes, bioenergetics, and regulation of biosynthesis. Provides students with basic essentials of modern biochemistry and the background needed for upper-division biology courses. Students who plan to do advanced work in biochemistry and molecular biology should take the Biochemistry and Molecular Biology 100 series directly. Students cannot receive credit for this course after they have completed any two courses from the BIOC 100A, BIOC 100B, and BIOC 100C sequence.

Credits

5

Instructor

Douglas Kellogg, Jeremy Sanford

Requirements

Prerequisite(s): BIOL 20A and BIOE 20B; and CHEM 8A or CHEM 112A.

Quarter offered

Fall, Winter, Spring

BIOL 100L Biochemistry Laboratory

Basic techniques and principles of laboratory biochemistry including isolation and characterization of a natural product, manipulation of proteins and nucleic acids to demonstrate basic physical and chemical properties; and characterization of enzyme substrate interactions. Students are billed a materials fee.

Credits

5

Requirements

Prerequisite(s): BIOL 100 or BIOC 100A; BIOL 101L or BIOL 102L; and satisfaction of the Entry Level Writing and Composition requirements. Enrollment is restricted to biological sciences and affiliated majors and biology minors. Non-majors may enroll by permission of the instructor.

BIOL 101 Molecular Biology

Covers the basic molecular mechanism of DNA replication and transcription, protein synthesis, and gene regulation in bacterial and eukaryotic organisms. The experimental techniques used to determine these mechanisms are emphasized. Unless students have already passed BIOL 20L, they are strongly encouraged to enroll in BIOL 101L.

Credits

5

Instructor

Melissa Jurica, Christopher Vollmers

Requirements

Prerequisite(s): BIOL 100 or BIOC 100A.

Quarter offered

Winter, Spring

BIOL 101L Molecular Biology Laboratory

Laboratory course providing hands-on experience with, and covering conceptual background in, fundamental techniques in molecular biology and biochemistry, including DNA cloning, PCR, restriction digest, gel electrophoresis, protein isolation, protein quantification, protein immunoblot (Western) analysis, and use of online bioinformatics tools. Students are billed a materials fee.

Credits

2

Requirements

Prerequisite(s): Previous or concurrent enrollment in BIOL 20L or BIOL 102J, and BIOL 101 or BIOC 100A is required. Students cannot receive credit for this course and BIOL 102L. Enrollment is restricted to biochemistry and molecular biology, biology B.S., molecular, cell, and developmental biology, and neuroscience majors.

Quarter offered

Winter, Spring, Summer

BIOL 102J Toxic RNA Lab I

Introduction to hypothesis-driven laboratory research. Students will create models of a unique uncharacterized disease causing mutation using site directed mutagenesis. An understanding of introductory molecular biology and genetics required. Students are billed a materials fee. Prerequisite(s): BIOL 20A. Enrollment restricted to biological sciences and affiliated majors with sophomore standing or higher. Enrollment by application and permission of instructor.

Credits

5

Quarter offered

Fall

BIOL 102L Toxic RNA Lab II

Introduces hypothesis-driven laboratory research. Students create models of a unique uncharacterized disease causing mutation and determine how it impacts the process of pre-mRNA splicing. An understanding of introductory molecular biology and genetics is required. Students are billed a materials fee. Prerequisite(s): BIOL 20A; and BIOL 20L or BIOL 102J. Enrollment is restricted to sophomore, junior, and senior biological sciences and affiliated majors. Enrollment is by application and permission of the instructor.

Credits

5

General Education Code

PR-E

Quarter offered

Winter

BIOL 103L Toxic RNA Lab III

Introduces hypothesis-driven laboratory research. Students create models of a unique, uncharacterized, disease-causing mutation and determine how it impacts the process of pre-mRNA splicing. An understanding of introductory molecular biology and genetics is required. Prerequisite(s): BIOL 102J and BIOL 102L and satisfaction of the Entry Level Writing and Composition is requirements. Enrollment is restricted to sophomores, juniors, and seniors majoring in biology, molecular, cell, and developmental biology, neuroscience, human biology, and biochemistry and molecular biology. Enrollment is by application and permission of the instructor.

Credits

5

Quarter offered

Spring

BIOL 105 Genetics

Mendelian and molecular genetics; mechanisms of heredity, mutation, recombination, and gene action.

Credits

5

Instructor

Susan Strome, Jeremy Lee, Needhi Bhalla

Requirements

Prerequisite(s): BIOL 20A and BIOE 20B.

Quarter offered

Fall, Winter, Spring, Summer

BIOL 105L Eukaryotic Genetics Laboratory

Classical and newly developed molecular-genetic techniques used to explore genetic variation in wild populations of the fruit fly Drosophila melanogaster. Topics include Mendelian fundamentals, mapping, design of genetic screens, bio-informatic and database analysis, genetic enhancers, and population genetics. Students are billed a materials fee. Enrollment is restricted to biological sciences and affiliated majors; biology minors; non-majors by instructor permission.

Credits

5

Instructor

The Staff

Requirements

Prerequisite(s): BIOL 100 or BIOC 100A; BIOL 101L or BIOL 102L; BIOL 105; and satisfaction of the Entry Level Writing and Composition Requirements.

Quarter offered

Fall, Winter, Spring

BIOL 109L Yeast Molecular Genetics Laboratory

Using budding yeast as an experimental organism, this laboratory provides practical experience in classic and modern molecular biology and in genetic and epigenetic methods, and develops strong scientific communication skills. Topics include mendelian genetics, linkage, gene replacement, chromatin immunoprecipitation and epigenetics. Students are billed a materials fee.

Credits

5

Requirements

Prerequisite(s): BIOL 101 or BIOC 100A; and BIOL 101L or BIOL 102L, and BIOL 105. BIOL 115 strongly recommended. Satisfaction of the Entry Level Writing and Composition requirements. Enrollment is restricted to biological sciences and affiliated majors; biology minors. Non-majors enroll by instructor permission.

Quarter offered

Fall, Winter, Spring

BIOL 110 Cell Biology

Covers the structure, organization, and function of eukaryotic cells. Topics include biological membranes, organelles, protein and vesicular trafficking, cellular interactions, the cytoskeleton, and signal transduction. Requires a good understanding of basic biochemistry and molecular biology.

Credits

5

Instructor

Lindsay Hinck, Michael Rexach

Requirements

Prerequisite(s): BIOL 101 or BIOC 100A; and BIOL 105; and BIOL 101L or BIOL 102L or BIOL 20L.

Quarter offered

Fall, Winter, Spring

BIOL 111 Immunology

Immune systems--their manifestations and mechanisms of action.

Credits

5

Requirements

Prerequisite(s): BIOL 20A, BIOE 20B, BIOL 105, and BIOL 110.

BIOL 111A Immunology I

Principles and concepts of the innate and adaptive immune systems, with emphasis on mechanisms of action and molecular and cellular networks. The development, differentiation, and maturation of cells of the immune system are also discussed.

Credits

5

Instructor

Susan Carpenter

Requirements

Prerequisite(s): courses BIOE 20B, BIOL 20A, BIOL 105, and BIOL 110.

Quarter offered

Winter

BIOL 111B Immunology II

The immune system in health and disease, including failures of host immune-defense mechanisms, allergy and hypersensitivity, autoimmunity, transplantation biology, the immune response to tumors, immune-system interactions with pathogens, and manipulation of the immune response.

Credits

5

Instructor

Martha Zuniga

Requirements

Prerequisite(s): BIOL 111A.

Quarter offered

Spring

BIOL 112 Virology

Principles of virology illustrated through study of specific examples. Topics include: viral genome organization, viral assembly, virus-host interactions, genetic diversity of viruses, viral ecology, and the epidemiology of viral diseases. Prerequisite(s): BIOL 101 and 110 and consent of instructor.

Credits

3

Instructor

Martha Zuniga

Quarter offered

Winter

BIOL 114 Cancer Cell Biology

Focuses on the molecular and cellular mechanisms behind cancer. Topics covered include oncogenes, tumor suppressor genes, cell growth genes, checkpoint genes, telomeres, and apoptosis. Students will gain experience in reading the primary scientific literature.

Credits

5

Instructor

Alan Zahler

Requirements

Prerequisite(s): BIOL 110 or BIOL 115.

General Education Code

TA

Quarter offered

Spring

BIOL 115 Eukaryotic Molecular Biology

Covers eukaryotic gene and genome organization; DNA, RNA, and protein synthesis; regulation of gene expression; chromosome structure and organization; and the application of recombinant DNA technology to the study of these topics.

Credits

5

Instructor

Hanns Boeger

Requirements

Prerequisite(s): BIOL 101 or BIOC 100A; and BIOL 105; and BIOL 101L or BIOL 102L. Enrollment restricted to biological sciences and affiliated majors, non-majors by permission of instructor.

Quarter offered

Winter

BIOL 115L Eukaryotic Molecular Biology Laboratory

A laboratory designed to provide students with direct training in basic molecular techniques. Each laboratory is a separate module which together builds to allow cloning, isolation, and identification of a nucleic acid sequence from scratch. Students cannot receive credit for this course and BIOL 187L or BIOL 287L. Students are billed a materials fee.

Credits

5

Requirements

Prerequisite(s): BIOL 100 or BIOC 100A; BIOL 101L or BIOL 102L; and satisfaction of the Entry Level Writing and Composition Requirements; and previous or concurrent enrollment in BIOL 101 or BIOL 115. Restricted to molecular, cell and developmental biology majors and affiliated majors; biology minors; other majors by permission.

Quarter offered

Fall, Winter, Spring

BIOL 116 Advanced Topics in Cell Biology

Advanced course in cell biology featuring small-classroom discussion of topics related to the structure and function of cells and their organelles. Emphasis is given to experimental strategies used in cell biology research. Requires discussion of scientific literature and student-led presentations.

Credits

3

Instructor

Michael Rexach

Requirements

Prerequisite(s): BIOL 110. Enrollment is restricted to senior human biology, molecular, cell, and developmental biology, and neuroscience majors. Other majors by permission of instructor.

Quarter offered

Spring

BIOL 117 Global Health and Neglected Diseases

Neglected tropical diseases afflict more than 1 billion of the poorest individuals on the planet. This course covers the molecular basis and pathology of the most prevalent neglected diseases and emerging strategies to combat these diseases. (Formerly Neglected Tropical Diseases.)

Credits

3

Instructor

William Sullivan

Requirements

Prerequisite(s): BIOL 110. Enrollment is restricted to senior human biology, molecular, cell, and developmental biology, and neuroscience majors. Other majors by permission of instructor.

Quarter offered

Fall

BIOL 120 Developmental Biology

A description and analysis of selected developmental events in the life cycle of animals. Experimental approaches to understanding mechanisms are emphasized. (Formerly Development.)

Credits

5

Instructor

Zhu Wang

Requirements

Prerequisite(s): BIOL 110.

Quarter offered

Winter

BIOL 120L Development Laboratory

Experimental studies of animal development using a variety of locally obtainable organisms. Approximately eight hours weekly, but it will often be necessary to monitor continuing experiments throughout the week. Students are billed a materials fee.

Credits

5

Requirements

Prerequisite(s): BIOL 100 or BIOC 100A; and BIOL 101L or BIOL 102L; satisfaction of the Entry Level Writing and Composition requirements. Previous or concurrent enrollment in BIOL 120 is required. Enrollment is restricted to biological sciences and affiliated majors; biology minors; other majors by permission.

Quarter offered

Winter

BIOL 121L Environmental Phage Biology Laboratory

Introduction to hypothesis-driven laboratory research. Students isolate a unique bacteriophage and characterize its structure and genome. An understanding of molecular biology and basic genetics is required. Students are billed a materials fee. Prerequisite(s): BIOL 100 or BIOC 100A; and BIOL 101L or 102L; satisfaction of the Entry Level Writing and Composition requirements. Enrollment is restricted to biological sciences and affiliated majors with sophomore standing or higher. Enrollment is by application and permission of instructor.

Credits

5

BIOL 125 Introduction to Neuroscience

The structure and function of the nervous system. Topics include elementary electrical principles, biophysics and physiology of single nerve and muscle cells, signal transduction at synapses, development of the nervous system, and neural basis of behavior. Requires a good understanding of basic biochemistry, cell biology, and molecular biology.

Credits

5

Instructor

James Ackman

Requirements

Prerequisite(s): BIOL 20A, BIOE 20B; and BIOL 101 or BIOC 100A; previous or concurrent enrollment in BIOL 110 is required.

Quarter offered

Fall, Winter

BIOL 126 Advanced Molecular Neuroscience

Explores in detail cellular and molecular events that underlay the function of the nervous system. Topics include neural development, axon guidance and regeneration, advanced electrical principles (synaptic transmission through a variety of receptors), synaptic plasticity, learning and memory, as well as several neural disorders. Students cannot receive credit for this course and course 226.

Credits

5

Instructor

David Feldheim, Yi Zuo

Requirements

Prerequisite(s): BIOL 125. Enrollment is restricted to neuroscience majors and proposed majors.

General Education Code

TA

Quarter offered

Spring

BIOL 127 Mechanisms of Neurodegenerative Disease

Focuses on cellular and molecular processes that underlie neurodegenerative diseases. Includes lectures, student oral presentations, discussions, a term paper, and exams.

Credits

5

Instructor

William Saxton

Requirements

Prerequisite(s): BIOL 110.

BIOL 128 Developmental Neurobiology

Covers the principles of nervous-system development from the molecular control of development, cell-cell interactions, to the role of experience in influencing brain structure and function. Students cannot receive credit for this course and course 228.

Credits

5

Instructor

Bin Chen

Requirements

Prerequisite(s): BIOL 110 and BIOL 125. Enrollment is restricted to juniors and seniors.

Quarter offered

Winter

BIOL 130 Human Physiology

Function, organization, and regulation of the major organ systems of humans, with emphasis on integration among systems. Students cannot receive credit for this course and course 131.

Credits

5

Requirements

Prerequisite(s): BIOL 110.

Quarter offered

Fall, Winter, Summer

BIOL 130L Human Physiology Laboratory

Examines fundamental principles of systemic physiology focusing on the human. Students cannot receive credit for this course and BIOE 131L. Students are billed a materials fee.

Credits

2

Requirements

Prerequisite(s): BIOL 110; BIOL 20L or 102J; and previous or concurrent enrollment in BIOL130 is required.Satisfaction of Entry Level Writing and Composition requirements. Enrollment is restricted to biological sciences and affiliated majors; biology minors; other majors by permission.

Quarter offered

Fall, Winter, Summer

BIOL 140 The RNA World

This active-learning course explores the origins, evolution, and functions of ribonucleic acid (RNA), including ribozymes, ribosomes, IRNAs, spliceosomes, riboswitches, messenger RNA, microRNAs, snRNAs, snoRNAs, and other guide RNAs, CRISPR, long noncoding RNAs, retrotransposons, and RNA viruses.

Credits

5

Requirements

Prerequisite(s): BIOL 105 or BME 105, and BIOL 101.

Quarter offered

Spring

BIOL 186F Undergraduate Research in MCD Biology

Supervised undergraduate research in laboratory of an MCD biology faculty member accompanied by weekly lectures on ethical and practical scientific issues. Topics include: laboratory safety; the scientific method; the collection, treatment, and presentation of data; critical evaluation of scientific literature; scientific misconduct; and peer review. Career issues, including how to apply for admission to graduate and professional schools, are also discussed. Prerequisite(s): BIOL 100 or BIOC 100A; and BIOL 20L or BIOL 102J; and previous completion of the Disciplinary Communication requirement. Each enrolled student must have a committed MCD faculty sponsor by the first class meeting. Enrollment is restricted to biology and affiliated majors.

Credits

2

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 186L Undergraduate Research in MCD Biology

Supervised undergraduate research in laboratory of an MCD biology faculty member accompanied by weekly lectures on ethical and practical scientific issues. Topics include: laboratory safety; the scientific method; the collection, treatment, and presentation of data; critical evaluation of scientific literature; scientific misconduct; and peer review. Career issues, including how to apply for admission to graduate and professional schools, are also discussed. Prerequisite(s): Entry Level Writing and Composition requirements; BIOL 100 or BIOC 100A; and BIOL 20L or BIOL 102J. Each enrolled student must have a committed MCD faculty sponsor by the first class meeting. Enrollment is restricted to biology and affiliated majors.

Credits

5

Quarter offered

Fall, Winter, Spring

BIOL 186R Undergraduate Research in MCD Biology

Supervised undergraduate research in the laboratory of an MCD biology faculty member accompanied by weekly lectures on practical scientific issues. Topics include: laboratory safety; the scientific method; the collection, treatment, and presentation of data; critical evaluation of scientific literature; ethics and scientific misconduct; and peer review. Career issues, including how to apply for admission to graduate and professional schools, are discussed. Students cannot receive credit for this course and course 186L. Prerequisite(s): BIOL 100 or BIOC 100A; and BIOL 20L or BIOL 102J; and previous completion of the Disciplinary Communication requirement. Each enrolled student must have a committed MCD faculty sponsor by the first class. Enrollment is restricted to MCD Biology-affiliated majors.

Credits

5

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 188 A Life in Medicine

Students explore healthcare from the perspectives of both clinicians and patients. The class focuses on medicine's cognitive, emotional, and spiritual elements, with the goal of understanding the rewards and costs of healthcare practice. (Formerly Life in Healthcare.)

Credits

3

Requirements

Enrollment is restricted to junior and senior human biology majors, and others by permission of instructor.

General Education Code

PR-E

Quarter offered

Fall, Spring

BIOL 189 Health Sciences Internship

Structured off-campus learning experience providing experience and pre-professional mentoring in a variety of health-related settings. Interns are trained and supervised by a professional at their placement and receive academic guidance from their faculty sponsor. Students spend 8 hours per week at their placement, participate in required class meetings on campus, and keep a reflective journal. Enrollment is by application. Students interview with health sciences internship coordinator; applications are due one quarter in advance to the Health Sciences Internship Office. Prerequisite(s): satisfaction of the Entry Level Writing and Composition requirements; previous or concurrent enrollment in course 189W is required. Enrollment is restricted to human biology majors.

Credits

3

Instructor

Lindsay Hinck, Martha Zuniga, Michael Rexach

Quarter offered

Fall, Winter, Spring, Summer

BIOL 189W Disciplinary Communication: Human Biology

Writing-intensive course offered in conjunction with the health sciences internship. Weekly class meetings include academic guidance and mentoring as well as discussion of the mechanisms and conventions of academic writing about heath and health care. Students complete multiple writing assignments, culminating in a term paper in the format of a scholarly article. Enrollment is by application. Students interview with the health-sciences internship coordinator; applications are due one quarter in advance to the Health Care Sciences Internship Office. Prerequisite(s): satisfaction of the Entry Level Writing and Composition requirements. Previous or concurrent enrollment in course 189 is required. Enrollment is restricted to human biology majors.

Credits

2

Instructor

Lindsay Hinck, Martha Zuniga, Michael Rexach

Quarter offered

Fall, Winter, Spring, Summer

BIOL 195 Senior Thesis Research

An individually supervised course, with emphasis on independent research, to culminate in a senior thesis. Students submit petition to sponsoring agency.

Credits

5

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 198 Independent Field Study

Provides for individual programs of study (a) by means other than the usual supervision in person, or (b) when the student is doing all or most of the coursework off campus. With permission of the department, may be repeated for credit, or two or three courses taken concurrently. Students submit petition to sponsoring agency.

Credits

5

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 198F Independent Field Study

Provides for two credits of independent field study (a) by means other than the usual supervision in person, or (b) when the student is doing all or most of the coursework off campus. Students submit petition to sponsoring agency.

Credits

2

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 199 Tutorial

Reading, discussion, written reports, and laboratory research on selected biological topics, using facilities normally available on campus. Students submit petition to sponsoring agency.

Credits

5

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 199F Tutorial

Two-credit Tutorial. Reading, discussion, written reports, and laboratory research on selected biological topics, using facilities normally available on campus. Students submit petition to sponsoring agency.

Credits

2

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring