Graduate

BIOL 200A Critical Analysis of Scientific Literature

Development of critical thinking skills via discussion of research articles on a broad range of topics. Prepares students to critically evaluate research publications, and improves their ability to organize effective oral presentations and to evaluate the oral presentations of other scientists.

Credits

5

Instructor

John Tamkun, Jeremy Sanford

Requirements

Enrollment is restricted to graduate students in MCD biology, or by permission of instructor.

Quarter offered

Fall

BIOL 200B Advanced Molecular Biology

An in-depth coverage of the structure, function, and synthesis of DNA, RNA, and proteins. Discussion of the roles of macromolecules in the regulation of information in the cell.

Credits

5

Instructor

Alan Zahler, Melissa Jurica, Hanns Boeger

Requirements

Prerequisite(s): Enrollment is restricted to graduate students.

Quarter offered

Winter

BIOL 200C Advanced Cell Biology

An in-depth coverage of topics in cellular and subcellular organization, structure, and function in plants and animals. Emphasis on current research problems.

Credits

5

Instructor

Douglas Kellogg, William Saxton, Needhi Bhalla

Requirements

Prerequisite(s): BIOL 200B. Enrollment is restricted to graduate students.

Quarter offered

Spring

BIOL 200D Developmental Biology

Key topics in developmental biology, including developmental genetics, epigenetics, stem cell biology, and developmental neurobiology. Lectures are accompanied by critical analysis and discussion of recent publications.

Credits

5

Instructor

Susan Strome, Bin Chen, Zhu Wang

Requirements

Enrollment is restricted to graduate students in MCD biology, or by permission of instructor.

Quarter offered

Spring

BIOL 200E Experimental Design

A multidisciplinary course that focuses on topics to consider when tackling biomedical research questions experimentally. Lectures highlight important issues to take into account, are coupled with group discussions and intensive analysis of primary literature, and involve case studies to practically demonstrate how how these considerations might be implemented.

Credits

3

Requirements

Concurrent enrollment in BIOL 200A is required.

BIOL 200F Logic and Approaches to Scientific Discovery

Multidisciplinary course with an emphasis on discussion of approaches and methods involved in the study of biological questions. Lectures focus on current gaps in our knowledge of topics and approaches to test models and hypotheses. Course focuses on current topics in RNA and DNA molecular biology, cell biology, developmental biology, stem cells, neurobiology, and genomics. Lectures coupled with small group discussions and written assignments.

Credits

5

Requirements

Prerequisite(s): BIOL 200A. Enrollment is restricted to graduate students.

BIOL 201 RNA Processing

An advanced graduate-level course on biological aspects of RNA function and processing in eukaryotes. Lectures and discussions will be developed using the current literature.

Credits

5

Instructor

Manuel Ares, Melissa Jurica

Requirements

Prerequisite(s): BIOL 200B or permission of instructor. Enrollment is restricted to graduate students.

BIOL 203 Ribosomes and Translation

Covers the field of ribosome research in depth, including the structure and function of ribosomes and the molecular mechanisms of protein synthesis. Begins with historical review of the ribosome field and proceeds to the most recent findings. Focus is on central questions: (1) How is the accuracy of the aminoacyl-tRNA selection determined? (2) What is accommodation? (3) What is the mechanism of peptide bond formation (peptidyl transferase)? (4) What is the mechanism of translocation? (5) What are the mechanistic roles of the ribosome and translation factor EF-G in translocation? (6) To what extent is the mechanism of translation determined by RNA? (7) Why is RNA so well suited for the ribosome? (8) How did translation evolve from an RNA world?

Credits

5

Requirements

Prerequisite(s): BIOC 100A, BIOL 200B or permission of instructor. Enrollment is restricted to graduate students.

BIOL 204 Chromatin

Eukaryotic DNA is complexed with histones to form chromatin. This course focuses on the ways in which chromatin influences and is manipulated to regulate gene expression

Credits

5

Instructor

Grant Hartzog, John Tamkun

Requirements

Prerequisite(s): BIOL 105 and BIOL 115; undergrads by permission of instructor. Enrollment is restricted to graduate students.

BIOL 205 Epigenetics

In-depth coverage of epigenetics focusing on how alterations in chromatin structure and DNA methylation establish and maintain heritable states of gene expression. Lectures are supplemented with critical discussion of recent publications.

Credits

5

Instructor

John Tamkun, Susan Strome

Requirements

Prerequisite(s): BIOL 105 and BIOL 115, or permission of instructor. Enrollment is restricted to graduate students.

BIOL 206 Introduction to Stem Cell Biology

Fundamental concepts, experimental approaches, and current advances in stem cell biology, with consideration of key ethical issues. Topics include: self-renewal and differentiation; the microenvironment; epigenetics; cell-cycle regulation; and how basic research translates to medical therapeutics. Ethical, moral, and political issues surrounding stem cell research are discussed with lectures from philosophy and other relevant disciplines.

Credits

5

Instructor

William Sullivan

Requirements

Enrollment is restricted to graduate students.

BIOL 206L Current Protocols in Stem Cell Biology

Provides students with hands-on experience in embryonic stem cell culture methods.

Credits

5

Instructor

David Feldheim, Yi Zuo

Requirements

Enrollment is restricted to graduate students; qualified undergraduates may enroll by permission of instructor.

BIOL 208 Cellular Signaling Mechanisms

All eukaryotic cells utilize intricate signaling pathways to control such diverse events as cell-cell communication, cell division, and changes in cell morphology. This course covers the molecular basis of these cellular signaling pathways, focusing on the most current research.

Credits

5

Instructor

Douglas Kellogg

Requirements

Prerequisite(s): BIOL 105, BIOL 110, and BIOL 115. Enrollment is restricted to seniors and graduate students.

BIOL 214 Advances in Cancer Biology

Provides students with knowledge of the latest concepts in cancer biology and cancer therapeutics, and a general appreciation of the rapid advances being made in this area of biomedicine.

Credits

5

Instructor

Lindsay Hinck

Requirements

Prerequisite(s): BIOL 200B or by permission of instructor. Enrollment is restricted to graduate students.

BIOL 215 Applied Statistics for Molecular, Cell, and Developmental Biology

For experimental biologists: focuses on resolving practical statistical issues typically encountered in molecular, cellular, and developmental biology lab research. No prior experience in statistics or programming is necessary.

Credits

5

Requirements

Enrollment is restricted to graduate students in molecular, cellular, and developmental biology.

BIOL 217 Influence of Environment and Experience on Brain Development

How environmental factors (animals' experiences, environmental toxins, etc.) affect the formation of neuronal circuits and brain function. Lectures and discussions use current literature.

Credits

5

Instructor

Donald Smith, Yi Zuo

Requirements

Prerequisite(s): BIOL 200A, BIOL 200B, BIOL 200C, and BIOL 200D, or by permission of the instructor. Enrollment is restricted to graduate students.

Quarter offered

Winter

BIOL 218 CRISPR/Cas Technologies

Provides an overview of the continually emerging roles for CRISPR in biomedical research. Topics will include an overview of the CRISPR genome defense systems in bacteria, the mechanisms of DNA cleavage and repair, the many uses of CRISPR as a genome editing tool in model organisms, and discussions on the ethical use of the technology in precision medicine.

Credits

5

Requirements

Prerequisite(s): BIOL 200A, BIOL 200B, and BIOL 200C. Enrollment restricted to graduate students.

Quarter offered

Fall

BIOL 226 Advanced Molecular Neuroscience

Basis of neural behavior at the cellular, molecular and system levels. First half of course focuses on cellular, molecular, and developmental aspects of the nervous system and covers two sensory systems: olfaction and auditory. Last half of course concerns higher-level functions of the nervous system, such as processing and integrating information. Discusses human diseases and disorders.

Credits

5

Instructor

Yi Zuo

Requirements

Enrollment is restricted to graduate students.

Quarter offered

Spring

BIOL 228 Developmental Neurobiology

Covers the principles of nervous-system development from the molecular control of development, and cell-cell interactions, to the role of experience in influencing brain structure and function. Students cannot receive credit for this course and course 128. Enrollment is restricted to graduate students and by permission of the instructor.

Credits

5

Instructor

Bin Chen

Quarter offered

Winter

BIOL 280A Topics in Research on Molecular Genetics of Yeast

Intensive research seminar on the structure and function of the gene expression machinery in the simple eukaryote Saccharomyces cervisiae and its relationship to the human gene expression machinery.

Credits

2

Instructor

Manuel Ares

Requirements

Enrollment is restricted to graduate students; qualified undergraduates may enroll with approval of instructor.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 280B Chromatin Structure and Transcriptional Regulation

Weekly seminar on structure and gene regulatory function of chromatin. Discusses research of participants and relevant scientific literature.

Credits

2

Instructor

Hanns Boeger

Requirements

Enrollment is restricted to graduate students; qualified undergraduates may enroll with permission of instructor.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 280C Mammalian Brain Development

Seminar covers research into the development of the mammalian brain.

Credits

2

Instructor

Bin Chen

Requirements

Enrollment is restricted to graduate students; undergraduates may enroll with permission of instructor.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 280D RNA Processing

A discussion of current research and literature concerning the regulation of precursor messenger RNA processing.

Credits

2

Instructor

Alan Zahler

Requirements

Enrollment is restricted to graduate students; qualified undergraduates may enroll with permission of instructor.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 280E Meiotic Chromosome Dynamics

Intensive course on the molecular mechanisms underlying homolog pairing, synapses, and recombination; and how they are regulated, coordinated, and monitored to ensure accurate meiotic chromosome segregation.

Credits

2

Instructor

Needhi Bhalla

Requirements

Enrollment is restricted to graduate students; undergraduates may enroll with permission of instructor.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 280F Development of Vertebrate Neural Connections

Intensive research seminar on molecular mechanisms by which neural connections are established during mouse development. Special focus on topographic maps and role of Eph receptors and ephrins in this process.

Credits

2

Instructor

David Feldheim

Requirements

Enrollment is restricted to graduate students; qualified undergraduates may enroll with permission of instructor.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 280G Physiology of the Developing Brain

Research seminar covering circuit structure and function in the developing brain.

Credits

2

Instructor

James Ackman

Requirements

Enrollment is restricted to graduate students; undergraduates may enroll by permission of the instructor.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 280H Topics on Research into Chromatin and Transcription

Seminar covering research into the effects of chromatin on transcription in yeast.

Credits

2

Instructor

Grant Hartzog

Requirements

Enrollment is restricted to graduate students; undergraduates may enroll with permission of instructor.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 280I Epigenetic Gene Silencing and Insulators

Intensive course on molecular mechanisms by which insulator elements regulate epigenetic gene silencing.

Credits

2

Instructor

Rohinton Kamakaka

Requirements

Enrollment is restricted to graduate students; qualified undergraduates may enroll with permission of instructor.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 280J Structures of Macromolecular Complexes

Focuses on structure and function of the spliceosome using electron microscopy and x-ray crystallography. Participants present results from their own research and relevant journal articles.

Credits

2

Instructor

Melissa Jurica

Requirements

Enrollment is restricted to graduate students; qualified undergraduates may enroll with permission of instructor.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 280K Topics in Cell Cycle Research

An intensive seminar focusing on current research on the molecular mechanisms that control cell division. Participants are required to present results of their own research or to review journal articles of interest.

Credits

2

Instructor

Douglas Kellogg

Requirements

Enrollment is restricted to graduate students; qualified undergraduates may enroll with permission of instructor.

Quarter offered

Fall, Winter, Spring

BIOL 280L Development

Seminar covering research into breast development and cancer. (Formerly Topics on Neural Development.)

Credits

2

Instructor

Lindsay Hinck

Requirements

Enrollment is restricted to graduate students.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 280M Post-Transcriptional Control of Mammalian Gene Expression

Intensive course on the molecular mechanisms by which RNA binding proteins regulate gene expression.

Credits

2

Instructor

Jeremy Sanford

Requirements

Enrollment is restricted to graduate students; qualified undergraduates may enroll with the permission of the instructor.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 280N Long Noncoding RNA and the Immune System

Weekly seminar discussion of the current research and literature concerning the functions for long noncoding RNA in gene regulation within inflammatory signaling pathways.

Credits

2

Instructor

Susan Carpenter

Requirements

Enrollment is restricted to graduate students; qualified undergraduates may enroll by permission of the instructor.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 280P Quality Control in Gene Expression

Intensive, discussion-based course concerning ongoing research in quality control and gene expression via analysis of published and unpublished observations and theories.

Credits

2

Instructor

Joshua Arribere

Requirements

Enrollment is restricted to graduate students.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 280Q Cell Biology of Oocytes, Embryos, and Neurons

Weekly seminar and round-table discussion about research problems and recent advances in molecular motor proteins, cytoskeletons, and the control of force-producing processes. Each participant reports recent advances in their field from current literature, their own primary research questions, current approaches to answering those questions, and their research progress.

Credits

2

Instructor

William Saxton

Requirements

Enrollment is restricted to graduate students; undergraduates may enroll with permission of instructor.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 280R Gene regulation in C. elegans and human parasitic namtodes

Intense weekly seminar on the mechanisms of gene regulation, focusing on C. elegans and human parasitic nematodes.

Credits

2

Instructor

Jordan Ward

Requirements

Enrollment is restricted to graduate students; qualified undergraduates may enroll with the permission of the instructor.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 280S Chromatin and RNA Regulation in <i>C. elegans</i>

Intensive research seminar about regulators of chromatin organization; the composition and function of germ granules; and the roles of both levels of regulation in germline development in C. elegans. Participants present their research results and report on related journal articles.

Credits

2

Instructor

Susan Strome

Requirements

Enrollment is restricted to graduate students; undergraduates may enroll with permission of instructor.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 280T Molecular Biology of <I>Drosophila</I> Development

An intensive seminar concerning the molecular genetics of Drosophila. Recent research is discussed weekly, with an emphasis on gene regulation and development. Students present their own research or critical reviews of recent articles at least once during the quarter.

Credits

2

Instructor

John Tamkun

Requirements

Enrollment is restricted to graduate students. Qualified undergraduates may enroll with permission of instructor.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 280U Discussions on the Development of the <I>Drosophila</I> Embryo

Involves a two-hour weekly meeting in which the students discuss topics concerning the cell cycle, early embryonic development, and the cytoskeleton. These discussions critically evaluate ongoing research in this area. Material is drawn from student research and recently published journal articles. Students are also expected to meet individually with the instructor two hours weekly. In addition to a three–five page research proposal, each student gives two one-hour oral presentations.

Credits

2

Instructor

William Sullivan

Requirements

Enrollment is restricted to graduate students; qualified undergraduates may enroll with permission of instructor.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 280V Translational pediatric genomics

Weekly discussion of the current research and literature on translational pediatric genomics. Specific patient cases may be discussed.

Credits

2

Requirements

Enrollment is restricted to graduate students; qualified undergraduates may enroll by permission of the instructor.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 280W Development, Connectivity, and Genetic Identity of Neural Circuits

This seminar course will cover the current topics and progress of neuroscience research on neural circuit development, connectivity, function and genetics. (Formerly Membrane Proteins.)

Credits

2

Requirements

Enrollment is restricted to graduate students; qualified undergraduates may enroll with permission of instructor.

Repeatable for credit

Yes

Quarter offered

Fall

BIOL 280X RNA-mediated epigenetic inheritance

Intensive research seminar about epigenetic inheritance and the role of small non-coding RNAs in the intergenerational inheritance of paternal environmental effects. Participants present their research results and report on related journal articles.

Credits

2

Requirements

Enrollment is restricted to graduate students; qualified undergraduates may enroll by permission of the instructor.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 280Y Activity-Dependent Synaptic Plasticity

Research seminar covering the regulation of synaptic plasticity in the mammalian nervous system, focusing on how the activity regulates the structural and functional dynamics of synapses.

Credits

2

Instructor

Yi Zuo

Requirements

Enrollment is restricted to graduate students; undergraduates may enroll with permission of instructor.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 280Z Prostate Development and Cancer Biology

Weekly research seminar covering gene regulation, cellular interactions, and stem cell behaviors in mammalian prostate development and prostate cancer progression.

Credits

2

Instructor

Zhu Wang

Requirements

Enrollment is restricted to graduate students; undergraduates may enroll by the permission of the instructor.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 288 Pedagogy in STEM

Prepares graduate students to help teach university science courses. Weekly class sessions include activities and interactive discussions of diverse modes of learning, diverse ways of teaching, peer instruction, assessment of learning, equity and inclusion, and professional ethics. Students also visit an active learning class and an active learning discussion section at UCSC, then write evaluations of the teaching strategies used in those classes. (Formerly Teaching Assistant Training.)

Credits

2

Instructor

Melissa Jurica, Susan Strome

Requirements

Enrollment is restricted to graduate students.

Quarter offered

Fall

BIOL 289 Practice of Science

Examination of ethical and practical scientific issues, including the collection and treatment of data, attribution of credit, plagiarism, fraud, and peer review. Career issues, including how to apply for grants and positions in industry or academia, will be discussed.

Credits

5

Instructor

William Saxton

Requirements

Prerequisite(s): BIOL 200A, BIOL 200B, and BIOL 200C or permission of instructor. Enrollment is restricted to graduate students; undergraduates may enroll with permission of the instructor.

Quarter offered

Spring

BIOL 290 Career Planning

An important goal of graduate programs is to train students for diverse careers. Exposes molecular cell and developmental biology graduate students to diverse career options and helps them develop individual development plans to target their graduate training to their selected career goals.

Credits

2

Instructor

Needhi Bhalla

Requirements

Enrollment is restricted to graduate students.

BIOL 291 Molecular, Cellular, and Developmental Biology Seminar

Topics of current interest in molecular, cellular, and developmental biology are presented weekly by graduate students, faculty, and guest speakers.

Credits

2

Instructor

David Feldheim

Requirements

Enrollment is restricted to graduate students.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 292 MCD Seminar

Various topics by weekly guest speakers.

Credits

0

Instructor

David Feldheim

Requirements

Enrollment is restricted to graduate students.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 296 Laboratory Research in Molecular, Cell, and Developmental Biology

Independent laboratory research in molecular, cellular, and developmental biology. Students submit petition to sponsoring agency.

Credits

5

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 297A Independent Study

Independent study for graduate students who have not yet settled on a research area for their thesis. Students submit petition to sponsoring agency.

Credits

5

Repeatable for credit

Yes

BIOL 297B Independent Study

Independent study for graduate students who have not yet settled on a research area for their thesis. Students submit petition to sponsoring agency.

Credits

10

Repeatable for credit

Yes

BIOL 297C Independent Study

Independent study for graduate students who have not yet settled on a research area for their thesis. Students submit petition to sponsoring agency.

Credits

15

Repeatable for credit

Yes

BIOL 297F Independent Study

Independent study for graduate students who have not yet settled on a research area for their thesis. Students submit petition to sponsoring agency.

Credits

2

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring, Summer

BIOL 299A Thesis Research

Students submit petition to sponsoring agency.

Credits

5

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 299B Thesis Research

Students submit petition to sponsoring agency.

Credits

10

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 299C Thesis Research

Students submit petition to sponsoring agency.

Credits

15

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring

BIOL 299F Thesis Research

Students submit petition to sponsoring agency.

Credits

2

Requirements

Enrollment is restricted to graduate students.

Repeatable for credit

Yes

Quarter offered

Fall, Winter, Spring, Summer